This book constitutes the proceedings of the 24th International Conference on Discovery Science, DS 2021, which took place virtually during October 11-13, 2021.The 36 papers presented in this volume were carefully reviewed and selected from 76 submissions. The contributions were organized in topical sections named: applications; classification; data streams; graph and network mining; machine learning for COVID-19; neural networks and deep learning; preferences and recommender systems; representation learning and feature selection; responsible artificial intelligence; and spatial, temporal and spatiotemporal data.