Biomimetics provide new strategy that translates our knowledge of biological system and create new synthetic pathways to mimic biological processes. Three approaches are being used for the creation of new tissues by mimicking natural ones which includes the tissue engineering triad; the cells, mediators and a biocompatible matrix. It is a challenge to design and fabricate new biomimetic materials like enamel, dentin, cementum, pulp, bone and periodontal ligament. Focusing on to the future, we should direct our goal to regenerate the diseased and necrotic tissues rather than replacing them with some conventional replacement materials.