The Life Science industry has been subject to a digital revolution upending all facets of the value chain with data-driven approaches like Gene Therapy, Personalized Medicine, Advanced Cell and Tissue Engineering, Industry 4.0, Artificial Intelligence, Blockchain, Digital Twins, Internet-of-Medical-Things (IoMT) and Software-as-a-Medical-Device (SaMD). Our edited volume offers comprehensive coverage of the digital disruption sweeping through the industry. From drug discovery to manufacturing and life-cycle management, we explore the profound impact of digitalization. Our authors delve into open innovation, sci-fi prototyping, and the digital transformation of medical imaging and healthcare. This volume goes beyond theory to provide practical insights. We present business-oriented case studies, examine M&A topics, venture capital, and other investor perspectives, all with a strong focus on digitalization's role. Furthermore, we explore the cultural and ethical challenges that arise andthe necessary management changes demanded by this digital revolution.