This research and reference text explores the finer details of Deep Learning models. It provides a brief outline on popular models including convolution neural networks (CNN), deep belief networks (DBN), autoencoders, residual neural networks (Res Nets). The text discusses some of the Deep Learning-based applications in gene identification. Sections in the book explore the foundation and necessity of deep learning in radiology, the application of deep learning in the area of cardiovascular imaging and deep learning applications in the area of fatty liver disease characterization and COVID19, respectively.