This book constitutes the refereed proceedings of the 5th International Symposium on Parallel and Distributed Processing and Applications, ISPA 2007, held in Niagara Falls, Canada, in August 2007. The 83 revised full papers presented together with three keynote are cover algorithms and applications, architectures and systems, datamining and databases, fault tolerance and security, middleware and cooperative computing, networks, as well as software and languages.