Groundwater is one of the essential sources to humankind, but there has been an increasing load to this precious resource has become necessary to study it in detail with hydrogeological as well as geological aspects to understand the character of the groundwater resource and additionally embrace socioeconomic side so as to manage it well and use it in an exceedingly sustainable method, vulnerability assessment of the resource is conducted to focus on the area units that are highly vulnerable to degradation and presently appropriate call will be taken to safeguard the resource. This study aims to produce an outline of fluoride-contaminated groundwater in Ajmer District, India, by predicting affected areas. The prevalence of endemic pathology in numerous elements of Ajmer District has been widely reported, therefore, it is necessary to demarcate the fluoride-affected areas to adopt remedial measures. Overall, the abstraction and temporal variability in fluoride within the study space can pave the way to coming up with a method of managing groundwater resources to safeguard and provide potable water to dependent populations.