Human Computer Interfaces (HCIs) are the interactive Graphical Users Interfaces (GUIs), facilitate users to communicate through graphics like dialog box, wizards, menus, bars, scrolls, buttons, pointers, cursers, icons, messages on as well as touch mechanism, speech recognition, biometric, smart- sensing-processing-actuating (response) systems with computers for their daily needs of computing. Now a day''s business became very dynamic in nature, hence demand most sophisticated business application software''s (GUI/HCI) and supporting advanced integrated operating systems. These business software''s must be in the form of effective and efficient MIS/BIS/KBES/AI/CRM/ERP/SCM with strong DSS component along with high degree of users friendliness as well as most interactive and should be business centric, where machines acquire, understand and processing data with accepting users (from human side) with give output to them thorough HCI from machines (from computers side) in the form of information, knowledge, and intelligence based on users input data. This book would be very effective step to get start in the field of HCI/GUI