This book constitutes the refereed proceedings of the 8th International Conference on Artificial Intelligence and Soft Computing, ICAISC 2006, held in Zakopane, Poland, in June 2006. The 128 revised contributed papers presented were carefully reviewed and selected from 400 submissions. The papers are organized in topical sections on neural networks and their applications, fuzzy systems and their applications, evolutionary algorithms and their applications, rough sets, classification and clustering, image analysis and robotics, bioinformatics and medical applications, various problems of artificial intelligence.