This two-volume set LNCS 13398 and LNCS 13399 constitutes the refereed proceedings of the 17th International Conference on Parallel Problem Solving from Nature, PPSN 2022, held in Dortmund, Germany, in September 2022.The  87 revised full papers were carefully reviewed and selected from numerous submissions. The conference presents a study of computing methods derived from natural models. Amorphous Computing, Artificial Life, Artificial Ant Systems, Artificial Immune Systems, Artificial Neural Networks, Cellular Automata, Evolutionary Computation, Swarm Computing, Self-Organizing Systems, Chemical Computation, Molecular Computation, Quantum Computation, Machine Learning, and Artificial Intelligence approaches using Natural Computing methods are just some of the topics covered in this field.