A digital twin, in simple words, is a virtual model such that it accurately reflects an object or data. The usage of blockchain, along with the amalgamation of AI and big data, exploits the potential of the data generated from current industrial practices, giving rise to the digital twin model that can benefit from blockchain technology. This new book addresses this technology to actualize secure systems, networks, and environments. It details the modeling and simulation of blockchain-based digital twins and explores various applications along with challenges and opportunities. The volume explores its application in several industries, including healthcare, agriculture, and mechanics.