This book aims to share the theory and practice in innovative human/society-oriented information systems. The purpose of information technology is for people, communities, and societies, and we cannot ignore the human behavior and social features to design better information systems. The book includes the selected papers in the International Conference on Applied Informatics and Media Design 2019 (AIMD 2019) held at California State University, Bakersfield, USA, and International Conference on Applied Information Technologies 2021 (AIT 2021) held online, which are focused on information design, human–computer interaction, and social support systems. The book also contains multi-aspect contributions on applied informatics and media engineering, such as color design, online learning, creativity support, philosophical issues, elder treatment, AI, and business informatics.