Given the fundamental challenges to society in this era, a radical rewrite of how we approach science and culture is necessary. This handbook applies Perceptual Control Theory (PCT) to achieve a much needed convergence across the physical, life and social sciences, the humanities and arts. In doing so it addresses challenges such as mental illness, dementia, cancer care, toxic masculinity and societal oppression. It also reveals how PCT can be applied to practical issues such as understanding healthcare service implementation and human-machine interaction, as well as deeper questions such as consciousness and imagination. This second volume of the successful interdisciplinary handbook offers rich examples of how the unifying perceptual control framework can provide a viable alternative to existing theories and methodologies for a timely paradigm shift.