This volume of proceedings presents selected and peer reviewed papers from 4th International Conference on Intelligent Systems Design and Engineering Applications, which took place in Seoul, South Korea during April 19-21, 2025. The research topics covered in this book include Machine learning and deep learning, Cloud computing and cloud storage, Human-machine intelligent interaction system, Intelligent control and automatic detection technology, Intelligent manufacturing and design, Computer Aided Design and Manufacturing, Product Management and Manufacturing Information System. The book serves as a valuable reference for researchers, scholars and engineers working in this filed.