This volume gathers a selection of substantially expanded and revised contributions from the 33rd International Conference on Information Systems Development (ISD 2025), which captured cutting-edge research and insights under the theme “Empowering the Interdisciplinary Role of ISD in Addressing Contemporary Issues in Digital Transformation: How Data Science and Generative AI Contributes to ISD.” The contributions provide a comprehensive overview of the transformative potential of technology, highlighting the symbiosis between innovative technologies and organizational processes. As such, they explore topics such as digital transformation, data science, machine learning, generative AI, and the integration of cutting-edge technologies, emphasizing the crucial role of information systems in driving digital change. The book offers valuable insights for researchers, practitioners, and students who seek to understand and shape the future of information systems development in our rapidly evolving digital landscape.