This book constitutes the refereed proceedings of the Second IEEE International Workshop on Self-Managed Networks, Systems, and Services, SelfMan 2006, held in Dublin, Ireland in June 2006. The 12 revised full papers presented together with 3 work-in-progress papers were carefully reviewed and selected from 51 submissions. The papers are organized in topical sections on middleware and infrastructure for self-management, peer-to-peer and overlay networks, self-adaptation, self-managed mobile systems, and networking.