Drug discovery: Past, present and future.- Endothelium-derived hyperpolarizing factor - a critical appraisal.- Isoprenoid biosynthesis via the mevalonate-independent route, a novel target for antibacterial drugs?.- Glutamatergic involvement in psychomotor stimulant action.- Polyamines and cerebral ischemia.- The identification and development of antiviral agents for the treatment of hepatitis B virus infection.- Index Vol. 50.- Index of titles, Vol. 1-50.- Author and paper index, Vol. 1-50.