This book shares the lessons learned by a large community of educational researchers and science teachers as they designed, developed, and investigated a new technology-enhanced learning environment known as WISE: The Web-based Inquiry Science Environment. WISE offers a collection of free, customizable units on topics central to the science standards as well as guidance on how to exploit the Internet to improve learning and instruction in the science classroom (grades 6-12). Hundreds of teachers and over 100,000 students have learned from WISE projects taught in English, Norwegian, Dutch, German, Hebrew, Japanese, Chinese, and Korean.