With supply chains extending further and further, the usefulness of applying the Theory of Constraints (TOC) is becoming more evident. Today’s major companies are using TOC to transition from push to pull manufacturing. This new edition demonstrates TOC’s growth in importance applied to what the author refers to as the four Vs: variability, volatility, visibility, and velocity. This edition adds new chapters detailing the conflicts that large manufacturers face and the areas that every manufacturer must address: materials and supply chain management, project and portfolio management, and production control. Case studies reveal how TOC practices are implemented in the real world.