Life today is rife with rapid-fire “high alert” responses, a proliferating trend that is especially pronounced in the United States (though most certainly felt elsewhere as well), where past catastrophes shape expanding perceptions of imminent danger. September 11, 2001 looms as an inescapable spectral presence, defining an important baseline for the ramping up of biosecurity measures. However, the contributors to this volume argue against biosecurity as the new status quo by focusing instead on the ugly underbelly. Through considering the vulnerability of individuals and groups and particularly looking at how vulnerability propagates in the shadow of biosecurity, BioInsecurity and Vulnerability challenges the acceptance of surveillance measures or security interventions as necessities of life in the new millennium.