This volume contains the proceedings of the Second International Symposium on Growth Hormone (GH): Basic and Clinical Aspects, held in December 1992 to review current aspects of the rapidly expanding science of GH neuroendocrinology. The authors first present a background of neuroendocrine regulatory processes incorporating the roles of GHRH and somatostatin (SRIF) as major controllers of GH secretion. The book then proceeds to discuss the most recent information on the cellular and molecular mechanisms by which these compounds regulate GH secretion non-growth functions of GH, with major focus on GH and immune function generalized effects of GH in the aged GH insufficiency structural and functional analyses of GH secretagogues and current clinical studies involving GH.