The dawn of preservative and minimal intervention dentistry demonstrates that newer approaches for enamel remineralization are the need of the hour, independent of fluoride remineralizing systems. Non - fluoridated remineralization systems are not dependent on variables like saliva quality and patient compliance.However, most currently available non - fluoride remineralizing systems are based on improving efficacy of fluoride and reducing the possible fluoride concerns. There is a need for a biomimetic approach for regeneration of enamel in the long term which focuses on sturdy attachment of enamel apatite crystals to the tooth surface, akin to the creation of artificial enamel.