The Midwestern Conference on Combinatorics and Combinatorial Computing (MCCCC) has a long tradition dating back to the mid-1980s. After a 2-year hiatus due to the COVID-19 pandemic, mathematicians were eager to participate in MCCCC34, the 34th edition of this conference series, which took place from October 21st to 23rd, 2022, at Illinois State University. This volume collects peer-reviewed papers of the participants, covering topics in discrete mathematics and graph theory.